A few days ago

carbohydrates and its history?

carbohydrates and its history?

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A few days ago

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well carbohydrates were first identified way back in the age of rice in India … during sindu civilisation ….. they were testified in vedas as an essential food elements ……

for more modern view / chemical view check dis out


A few days ago
sriram v
Carbohydrates or saccharides (Greek σάκχαρον meaning “sugar”) are simple molecules that are straight-chain aldehydes or ketones with many hydroxyl groups added, usually one on each carbon atom that is not part of the aldehyde or ketone functional group. Carbohydrates are the most abundant biological molecules, and fill numerous roles in living things, such as the storage and transport of energy (starch, glycogen) and structural components (cellulose in plants, chitin in animals). Additionally, carbohydrates and their derivatives play major roles in the working process of the immune system, fertilization, pathogenesis, blood clotting, and development.

The basic carbohydrate units are called monosaccharides, such as glucose, galactose, and fructose. The general chemical formula of an unmodified monosaccharide is (C·H2O)n, where n is any number of three or greater. Monosaccharides can be linked together in almost limitless ways. Two joined monosaccharides are called disaccharides, such as sucrose and lactose. Carbohydrates containing between about three to six monosaccharide units are termed oligosaccharides; anything larger than this is a polysaccharide. Polysaccharides, such as starch, glycogen, or cellulose, can reach many thousands of units in length. Many carbohydrates contain one or more modified monosaccharide units that have had one or more groups replaced or removed. For example, deoxyribose, a component of DNA, is a modified version of ribose; chitin is composed of repeating units of N-acetylglucosamine, a nitrogen-containing form of glucose.

Monosaccharides are the simplest form of carbohydrates. They are aldehydes or ketones with many hydroxyl groups added, usually one on each carbon atom that is not part of the aldehyde or ketone functional group. They are called polyhydroxyl aldehydes or polyhydroxyl ketones respectively. The general chemical formula of an unmodified monosaccharide is (C·H2O)n, where n is any number of three or greater.

[edit] Classification of monosaccharides

The α and β anomers of glucose. Note the position of the anomeric carbon (red or green) relative to the CH2OH group bound to carbon 5: they are either on the opposite sides (α), or the same side (β).

Monosaccharides are classified according to three different characteristics: the placement of its carbonyl group, the number of carbon atoms it contains, and its chiral handedness. If the carbonyl group is an aldehyde, the monosaccharide is an aldose; if the carbonyl group is a ketone, the monosaccharide is a ketose. The smallest possible monosaccharide, those with three carbon atoms, are called trioses. Those with four are called tetroses, five are called pentoses, six are hexoses, and so on. These two systems of classification are often combined. For example, glucose is an aldohexose (a six-carbon aldehyde), ribose is an aldopentose (a five-carbon aldehyde), and fructose is a ketohexose (a six-carbon ketone).

Each carbon atom bearing a hydroxyl group (-OH), with the exception of the first and last carbons, are asymmetric, making them stereocenters with two possible configurations each (the -H and -OH may be on either side). Because of this asymmetry, a number of isomers may exist for any given monosaccharide formula. The aldohexose D-glucose, for example, has the formula (C·H2O)6, of which all but two of its six carbons atoms are chiral centers, making D-glucose one of 24 = 16 possible stereoisomers. In the case of a triose, there is one pair of possible stereoisomers, which are enantiomers and epimers. The assignment of D or L is made according to the orientation of the asymmetric carbon furthest from the carbonyl group: if the hydroxyl group is on the right the molecule is a D sugar, otherwise it is an L sugar. Because D sugars are biologically far more common, the D is often omitted.

[edit] Conformation

Pyran and furan, after which the pyranose and furanose configurations of monosaccharides are named.The aldehyde or ketone group of a straight-chain monosaccharide will react reversibly with a hydroxyl group on a different carbon atom to form a hemiacetal or hemiketal, forming a heterocyclic ring with an oxygen bridge between two carbon atoms. Rings with five and six atoms are called furanose and pyranose forms, respectively, and exist in equilibrium with the straight-chain form.

During the conversion from straight-chain form to cyclic form, the carbon atom containing the carbonyl oxygen, called the anomeric carbon, becomes a chiral center with two possible configurations: the oxygen atom may take a position either above or below the plane of the ring. The resulting possible pair of stereoisomers are called anomers. In the α anomer, the -OH substituent on the anomeric carbon rests on the opposite side of the ring from the CH2OH attached to the asymmetric carbon furthest from the anomeric carbon. The alternative form, in which the CH2OH and the anomeric hydroxyl are on the same side of the plane of the ring, is called the β anomer. Because the ring and straight-chain forms readily interconvert, both anomers exist in equilibrium.

[edit] Disaccharides

Sucrose, also known as table sugar, is a common disaccharide. It is composed of two linked monosaccharides: glucose (left) and fructose (right).Main article: Disaccharide

Disaccharides are the simplest polysaccharides. They are composed of two monosaccharide units bound together by a covalent glycosidic bond formed via a dehydration reaction, resulting in the loss of a hydrogen atom from one monosaccharide and a hydroxyl group from the other, so the formula of unmodified disaccharides is C12H22O11. Although there are numerous kinds of disaccharides, a handful of disaccharides are particularly notable.

Sucrose, pictured to the right, is the most abundant disaccharide and the main form in which carbohydrates are transported in plants. It is composed of one glucose molecule and one fructose molecule. The systematic name for sucrose, O-α-D-glucopyranosyl-(1→2)-D-fructofuranoside, indicates four things:

Its monosaccharides: glucose and fructose

Their ring types: glucose is a pyranose, and fructose is a furanose

How they’re linked together: the oxygen on the number 1 carbon (C1) of α-glucose is linked to the C2 of fructose.

The -oside suffix indicates that the anomeric carbon of both monosacchaides participates in the glycosidic bond.

Lactose, a disaccharide composed of one galactose molecule and one glucose molecule, occurs naturally only in milk. The systematic name for lactose is O-β-D-galactopyranosyl-(1→4)-D-glucopyranose. Other notable disaccharides include maltose (two glucoses linked α-1,4) and cellobiose (two glucoses linked β-1,4).

[edit] Oligosaccharides and polysaccharides

Amylose is a linear polymer of glucose mainly linked with α(1→4) bonds. It can be made of several thousands of glucose units. It is one of the two components of starch, the other being amylopectin.Main articles: Oligosaccharide and Polysaccharide

Oligosaccharides and polysaccharides are composed of longer chains of monosaccharide units bound together by glycosidic bonds. The distinction between the two is based upon the number of monosaccharide units present in the chain. Oligosaccharides typically contain between two and nine monosaccharide units, and polysaccharides contain greater than ten monosaccharide units. Definitions of how large a carbohydrate must be to fall into each category vary according to personal opinion. Examples of oligosaccharides include the disaccharides mentioned above, the trisaccharide raffinose and the tetrasaccharide stachyose.

Oligosaccharides are found as a common form of protein posttranslational modification. Such posttranslational modifications include the Lewis oligosaccharides responsible for blood group incompatibilities, the alpha-Gal epitope responsible for hyperacute rejection in xenotransplanation, and O-GlcNAc modifications.

Polysaccharides represent an important class of biological polymer. Examples include starch, cellulose, chitin, glycogen, callose, laminarin, xylan, and galactomannan.

[edit] Nutrition

Grain products are rich sources of complex carbohydratesCarbohydrates require less water to digest than proteins or fats and are the most common source of energy. Proteins and fat are vital building components for body tissue and cells, and thus it could be considered advisable not to deplete such resources by necessitating their use in energy production.

Carbohydrates are not essential nutrients: the body can obtain all its energy from protein and fats. The brain cannot burn fat and needs glucose for energy, but the body can make this glucose from protein. [editorial note: the “fat” entry for wikipedia also contains a reference to the liver making glucose from fat.] Carbohydrates, like proteins, contain 4 kilocalories per gram while fats contain 9 kilocalories and alcohol contains 7 kilocalories per gram.

Foods that are high in carbohydrates: Breads, pastas, beans, potatoes, bran, rice and cereals.

Based on evidence for risk of heart disease and obesity, the Institute of Medicine recommends that American and Canadian adults get between 40-65% of dietary energy from carbohydrates.[1] The Food and Agriculture Organization and World Health Organization jointly recommend that national dietary guidelines set a goal of 55-75% of total energy from carbohydrates, but only 10% should be from Free sugars (their definition of simple carbohydrates).[2]

The distinction between “good carbs” and “bad carbs” is a important attribute of low-carbohydrate diets, which promote a reduction in the consumption of grains and starches in favor of protein. The result is a reduction in insulin levels used to metabolize sugars, and an increase in the use of fat for energy through ketosis, a process also known as Rabbit starvation.

[edit] Classification

Dietitians and nutritionists commonly classify carbohydrates as simple (monosaccharides and disaccharides) or complex (oligosaccharides and polysaccharides). The term complex carbohydrate was first used in the Senate Select Committee publication Dietary Goals for the United States (1977), where it denoted “fruit, vegetables and whole-grains”.[3] Dietary guidelines generally recommend that complex carbohydrates and nutrient-rich simple carbohydrates such as fruit and dairy products should make up the bulk of carbohydrate consumption. The USDA’s Dietary Guidelines for Americans 2005 dispenses with the simple/complex distinction, instead recommending fiber-rich foods and whole grains.[4]

The glycemic index and glycemic load systems are popular alternative classification methods which rank carbohydrate-rich foods based on their effect on blood glucose levels. The insulin index is a similar, more recent classification method which ranks foods based on their effects on blood insulin levels. This system assumes that high glycemic index foods and low glycemic index foods can be mixed to make the intake of high glycemic foods more acceptable.[citation needed]

The World Health Organisation and Food and Agriculture Organization’s joint expert report on Diet, Nutrition and the Prevention of Chronic Diseases (WHO Technical Report Series 916) advises carbohydrate consumption of 55-75% carbohydrate, but restricts “Free sugar” intake to 10%. Its definition is “The term “free sugars” refers to all monosaccharides and disaccharides added to foods by the manufacturer, cook or consumer, plus sugars naturally present in honey, syrups and fruit juices.” (page 56 of the report; note to Table 6: Ranges of population nutrient intake goals). This is their effective split between simple and complex carbohydrates.

[edit] Metabolism

See main article: Carbohydrate metabolism

[edit] Catabolism

Catabolism is the metabolic reaction cells undergo in order to extract energy. There are two major metabolic pathways of monosaccharide catabolism:


Citric acid cycle

Oligo/polysaccharides are cleaved first to smaller monosaccharides by enzymes called Glycoside hydrolases. The monosaccharide units can then enter into monosaccharide catabolism.

[edit] Anabolism

Complex carbohydrates are assembled from sugar nucleotides by the action of glycosyltransferases.

[edit] Carbohydrate chemistry

Carbohydrates are reactants in many organic reactions. For example:

Carbohydrate acetalisation

Cyanohydrin reaction

Lobry-de Bruyn-van Ekenstein transformation

Amadori rearrangement

Nef reaction

Wohl degradation

Koenigs-Knorr reaction

An artificial carbohydrate is sorbitol.